How can CBD cure Alzheimer’s disease?
Alzheimer’s and CBD
WHAT IS ALZHEIMER’S DISEASE?
Alzheimer’s Disease is a progressive mental deterioration that can occur in middle or old age, due to generalized degeneration of the brain. It’s characterized by memory loss, confusion, and problems communicating. About one in ten people over 65, and one in three people over 85 have Alzheimer’s disease. Alzheimer’s is more common in women than men.
CBD, ALZHEIMER’S AND MORE
Despite the growing investigation on cannabis medicine for a wide variety of conditions, the actual healing power of the plant has barely been tapped.
Alzheimer’s disease is the neurodegenerative, chronic disorder which is linked to the progressive neuronal loss along with the cognitive decline that affects the elderly patients aged between 65 to 80 years.
The causes of Alzheimer’s disease are multi-factorial such as genetic origin along with unknown etiology.
AD patients suffer from cognitive impairment, speech difficulty along with short or long-term memory loss. Psychosis, depression and aggressive behavior characterize Alzheimer’s disease.
Alzheimer’s disease is one of the types of dementia which results in havoc for a person’s memory along with his behavior and thoughts.
The symptoms of Alzheimer’s disease worsen slowly, and every case varies from the other. However, the results are typically the same. This condition makes your daily activities extremely difficult with time and cannot be managed by the patient or the caregiver.
Alzheimer’s disease is one of the most common forms of dementia, and around 60-80% cases are diagnosed with dementia.
According to the findings, there is a massive number of public suffering from this disease:
- 45%- the people who are at risk of developing dementia and increase up to 45% primarily for smokers.
- 65%- the people who are diagnosed are especially women and aged around 65 years or above.
There’s a considerable number of people suffering from this tragic disease, due to which there is a drive to find new and effective medications to treat Alzheimer’s disease. One of such natural alternatives includes the use of CBD oil.
How can CBD cure Alzheimer’s disease?
Alzheimer’s disease results in severe effects till the patients can no longer take care for himself. Unfortunately, until this time there is no cure for this disastrous disease. However, CBD or cannabis oil can help in slowing down the progression of Alzheimer’s disease.
- Mechanism action of CBD for curing the Alzheimer’s disease
- Cannabis interacts with the receptors present in the endocannabinoid system, i.e., the CB1 and CB2 receptors.
- The CB1 receptors are present in the hippocampus area which is involved in the memory and learning centre whereas CB2 receptors are found in the specialized type of immune cells, i.e., microglia.
- The hippocampus area is involved in the Alzheimer’s disease which is vulnerable to the underlying causes linked with this disease. It contributes towards the problems associated with learning and memory issues related to the Alzheimer’s disease.
- It is also believed that microglia cells are also involved in the progression of this disease. Some studies, also conclude that patients with Alzheimer’s disease have increased the number of the CB2 receptors present in the brain.
- Cannabis oil has an anti-inflammatory effect
Neurodegenerative conditions, for example, Multiple Sclerosis, Parkinson’s and Alzheimer’s disease, often involve the inflamed neural tissues. During the initial stages of inflammation, it is thought that inflammatory phase serves as a defence mechanism.
However, in later stages, it leads to the uncontrolled chain reactions resulting in chronic neuronal inflammation along with deterioration.
If you consume Cannabis oil as a natural anti-inflammatory alternative, it helps in slowing down the progression of Alzheimer’s disease.
Cannabis oil serves as an anti-oxidant agent. The key components involved in Alzheimer’s disease are oxidative stress and reactive oxygen which are tied to the immune inflammation.
During inflammation, the oxidative stress is generated which results in the reduction of antioxidant function of the cells.
The oxidative stress further leads to the production of free radicals and chemical reactions with the fatty acids and proteins present within the cell membrane.
When Amyloid Beta-protein is present, it results in the elevation of a reactive type of oxygen species in the adjoining cells through the exchange process with the membranes.
The overall oxidative stress process leads to the neuronal loss along with the loss of synapses within the brain which leads to memory loss and other neurological symptoms.
So, during this condition, an antioxidant, i.e., CBD oil will help in slowing down the Alzheimer’s disease.
Cannabis oil serves as a neurogenesis stimulant
CBD oil is gaining attention for serving as a neurogenesis stimulant, i.e., it aids in the formation of the neural tissues by the neurogenesis process.
During the Alzheimer’s disease, the neural tissues rapidly deteriorate resulting in debilitating neurological impacts such as cognitive loss, memory loss along with severe changes in behavior or personality.
In fact, during this condition people who were seen as kind, loving and gentle can turn in to selfish and mean individuals due to which their loved ones have difficulty in understanding them.
CBD oil is believed to help in the formation of neurons and aids in slowing down the progression of Alzheimer’s disease.
Research studies and educational resources
According to some research, the role of the endocannabinoid system is a potential target for the treatment of the Alzheimer’s disease.
Some studies have shown that the components of the Cannabis, i.e., THC aids in removing the Alzheimer’s hallmark Amyloid Beta-protein clumps present in the nerve cells which are grown in the lab.
According to another study, a combination of CBD and THC were given to the mice that showed the Alzheimer disease symptoms were improved with it.
The learning capability was enhanced, and the amyloid clumps were less evident in their bodies.
Other researchers believed that targeting CB2 receptors helped in controlling the activity of the microglia cells, preventing the harmful overactivation of the immune system within the brain.
However, still, there are no studies carried out on people to find out the effects of the CBD oil or its components on the treatment of the underlying causes of the Alzheimer’s disease.
However, laboratory studies showed some promising results, but there need further studies and research to find out the beneficial effects of CBD oil in people with Alzheimer’s disease.
You must notice that many of these studies show the use of a specific component of Cannabis in isolated form.
Even if some studies show that the single element has helped in reducing the risk of dementia, it does not include that the entire cannabis will result in same effects.
CBD strains have different levels of CBD and THC, so you need to aware of the type of Cannabis used and its consequences.
According to a research carried out by Tim Karl and Carl Group, to identify the properties of CBD, i.e., neuroprotective, anti-oxidant and anti-inflammatory effects in vitro. These features were concluded to benefit and cure the Alzheimer’s disease.
The in vivo studies show that CBD oil aids in reducing the reactive gliosis and the neuroinflammatory response which is associated with the Alzheimer’s disease.
The findings also conclude that CBD promotes the development and growth of neurons which in turn reduces the deteriorative effects related to the disease.
Some studies indicate that the use of CBD along with THC- a psychoactive compound leads to even more significant therapeutic effects for the treatment of Alzheimer’s disease.
According to a study, a drug containing a combination of CBD and THC leads to the reduction of gliosis along with the decreased buildup of alpha beta and tau.